Publications

(Lab folks in bold)

From the Li Lab:

The dynamics of hematopoiesis over the human lifespan.

Li H†, Côté PD, Kuoch M, Ezike J, Frenis K, Afanassiev A, Greenstreet L, Tanaka-Yano M, Tarantino G, Zhang S, Whangbo J, Butty VL, Moiso E, Falchetti M, Lu K, Connelly GG, Morris V, Wang D, Chen AF, Bianchi G, Daley GQ, Garg S, Liu D, Chou ST, Regev A, Lummertz da Rocha E, Schiebinger G, Rowe RG†. Nat Methods. 2025 Feb;22(2):422-434. doi: 10.1038/s41592-024-02495-0. Epub 2024 Dec 5. (pdf). †co-corresponding

Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer.

Connelly GG, Kirkland OO, Bohannon S, Lim DC, Wilson RM, Richards EJ, Tay DM, Jee H, Hellinger RD, Hoang NK, Hao L, Chhabra A, Martin-Alonso C, Tan EKW, Koehler AN, Yaffe MB, London WB, Lee PY, Krammer F, Bohannon RC, Bhatia SN, Sikes HD, Li H.Cell Rep Methods. 2022 Aug 22;2(8):100273. doi: 10.1016/j.crmeth.2022.100273. Epub 2022 Aug 4.

FACS and immunomagnetic isolation of early erythroid progenitor cells from mouse fetal liver.

Braun TW, Kuoch MK, Khandros E, Li H.STAR Protoc. 2021 Dec 29;3(1):101070. doi: 10.1016/j.xpro.2021.101070. eCollection 2022 Mar 18.

Work we’ve contributed to:

Simultaneous NOD1 and NOD2 Deletion in Hematopoietic Stem and Progenitor cells Promotes Long-Term Donor Chimerism.

Hawkes AA, Kasimsetty SG, Li H, Morris GP, Kurian SM, Almeida S, DeWolf SE, McKay DB. Transplant Cell Ther. 2026 Feb 2:S2666-6367(26)00065-5. doi: 10.1016/j.jtct.2026.01.031.

Dynamic activity of Erg promotes maturation of the hematopoietic system.

Tanaka-Yano M, Sugden WW, Wang D, Falchetti M, Badalamenti B, Côté P, Chin D, Goldstein J, George S, Rodrigues-Luiz GF, Lummertz da Rocha E, Li H, North TE, Gryder BE, Rowe RG. Blood Adv. 2026 Feb 10;10(3):759-773. doi: 10.1182/bloodadvances.2025017705.

Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development.

Vicenzi S, Gao F, Côté P, Hartman JD, Avsharian LC, Vora AA, Rowe RG, Li H, Skowronska-Krawczyk D, Crews LA. Geroscience. 2025 Aug;47(4):5449-5467. doi: 10.1007/s11357-025-01594-w. Epub 2025 Apr 15.

The epigenetic state of the cell of origin defines mechanisms of leukemogenesis.

Li Z, Fierstein S, Tanaka-Yano M, Frenis K, Chen CC, Wang D, Falchetti M, Côté P, Curran C, Lu K, Liu T, Orkin S, Li H, Lummertz da Rocha E, Hu S, Zhu Q, Rowe RG. Leukemia. 2025 Jan;39(1):87-97. doi: 10.1038/s41375-024-02428-y. Epub 2024 Oct 1.

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis.

Maynard AG, Pohl NK, Mueller AP, Petrova B, Wong AYL, Wang P, Culhane AJ, Brook JR, Hirsch LM, Hoang N, Kirkland O, Braun T, Ducamp S, Fleming MD, Li H, Kanarek N.Sci Adv. 2024 Feb 2;10(5):eadj9479. doi: 10.1126/sciadv.adj9479. Epub 2024 Jan 31.

Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease.

Wobma H, Kapadia M, Kim HT, Alvarez-Calderon F, Baumeister SHC, Duncan C, Forrest S, Gorfinkel L, Huang J, Lehmann LE, Li H, Schwartz M, Koreth J, Ritz J, Kean LS, Whangbo JS.Blood Adv. 2023 Aug 22;7(16):4647-4657. doi: 10.1182/bloodadvances.2023009729.

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery.

Boehnke N, Straehla JP, Safford HC, Kocak M, Rees MG, Ronan M, Rosenberg D, Adelmann CH, Chivukula RR, Nabar N, Berger AG, Lamson NG, Cheah JH, Li H, Roth JA, Koehler AN, Hammond PT.Science. 2022 Jul 22;377(6604):eabm5551. doi: 10.1126/science.abm5551. Epub 2022 Jul 22.

Pre-Li Lab:

Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.

Li H*, Natarajan A*, Ezike J, Barrasa MI, Le Y, Feder ZA, Yang H, Ma C, Markoulaki S, Lodish HF.Dev Cell. 2019 Apr 8;49(1):118-129.e7. doi: 10.1016/j.devcel.2019.01.026. Epub 2019 Feb 28.PMID: 30827895. *co-first

Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation.

Li H, Benson LA, Henderson LA, Solomon IH, Kennedy AL, Soldatos A, Bielekova B, Murphy J, Davies KJ, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Gorman MP, Duncan CN.Blood Adv. 2019 Feb 26;3(4):503-507. doi: 10.1182/bloodadvances.2018027417.

Pediatric CNS-isolated hemophagocytic lymphohistiocytosis.

Benson LA*, Li H*, Henderson LA, Solomon IH, Soldatos A, Murphy J, Bielekova B, Kennedy AL, Rivkin MJ, Davies KJ, Hsu AP, Holland SM, Gahl WA, Sundel RP, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Duncan CN, Gorman MP.Neurol Neuroimmunol Neuroinflamm. 2019 Apr 8;6(3):e560. doi: 10.1212/NXI.0000000000000560. eCollection 2019 May. *co-first

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH.J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.

Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System.

Solomon IH, Li H, Benson LA, Henderson LA, Degar BA, Gorman MP, Duncan CN, Lidov HG, Alexandrescu S.J Neuropathol Exp Neurol. 2018 Dec 1;77(12):1079-1084. doi: 10.1093/jnen/nly094.

Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment.

Li H, Lodish HF, Sieff CA.Hematol Oncol Clin North Am. 2018 Aug;32(4):701-712. doi: 10.1016/j.hoc.2018.04.005. Epub 2018 Jun 5.

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 7.

Unclogging sickle cell anaemia.

Li H, Lodish H.Nat Rev Mol Cell Biol. 2017 Apr;18(4):214. doi: 10.1038/nrm.2017.17. Epub 2017 Mar 1.

Characteristic peripheral blood smear findings in disorders of cobalamin metabolism.

Li H, Sieff C.Blood. 2016 Nov 24;128(21):2584. doi: 10.1182/blood-2016-08-736991.

Efficient CRISPR-Cas9 mediated gene disruption in primary erythroid progenitor cells.

Li H*, Shi J*, Huang NJ, Pishesha N, Natarajan A, Eng JC, Lodish HF.Haematologica. 2016 Jun;101(6):e216-9. doi: 10.3324/haematol.2015.135723. Epub 2016 Mar 11. *co-first

Robust ZFN-mediated genome editing in adult hemophilic mice.

Anguela XM, Sharma R, Doyon Y, Miller JC, Li H, Haurigot V, Rohde ME, Wong SY, Davidson RJ, Zhou S, Gregory PD, Holmes MC, High KA.Blood. 2013 Nov 7;122(19):3283-7. doi: 10.1182/blood-2013-04-497354. Epub 2013 Oct 1.

In vivo genome editing restores haemostasis in a mouse model of haemophilia.

Li H, Haurigot V, Doyon Y, Li T, Wong SY, Bhagwat AS, Malani N, Anguela XM, Sharma R, Ivanciu L, Murphy SL, Finn JD, Khazi FR, Zhou S, Paschon DE, Rebar EJ, Bushman FD, Gregory PD, Holmes MC, High KA.Nature. 2011 Jun 26;475(7355):217-21. doi: 10.1038/nature10177.

Assessing the potential for AAV vector genotoxicity in a murine model.

Li H, Malani N, Hamilton SR, Schlachterman A, Bussadori G, Edmonson SE, Shah R, Arruda VR, Mingozzi F, Wright JF, Bushman FD, High KA.Blood. 2011 Mar 24;117(12):3311-9. doi: 10.1182/blood-2010-08-302729. Epub 2010 Nov 24.

Diverse IgG subclass responses to adeno-associated virus infection and vector administration.

Murphy SL*, Li H*, Mingozzi F, Sabatino DE, Hui DJ, Edmonson SA, High KA.J Med Virol. 2009 Jan;81(1):65-74. doi: 10.1002/jmv.21360.P *co-first

Prolonged susceptibility to antibody-mediated neutralization for adeno-associated vectors targeted to the liver.

Murphy SL, Li H, Zhou S, Schlachterman A, High KA.Mol Ther. 2008 Jan;16(1):138-45. doi: 10.1038/sj.mt.6300334. Epub 2007 Oct 23.

Water-mediated association provides an ion pair receptor.

Kotch FW, Sidorov V, Lam YF, Kayser KJ, Li H, Kaucher MS, Davis JT.J Am Chem Soc. 2003 Dec 10;125(49):15140-50. doi: 10.1021/ja0364165.